Senior Medical Science Liaison (Northeast/U.S. Oncology)

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary

The Senior MSL is a U.S. field-based role within Medical Affairs, reporting to the Executive Director, Medical Affairs. This role will be a core member of Tango’s growing field medical team during a critical phase of development.

The Senior MSL will be responsible for high‑quality scientific exchange, trial execution support, medical education, and insight generation across priority solid tumor indications, with an initial focus on pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC), and our evolving pipeline programs.

This role is ideal for an individual who wants to operate at the intersection of clinical development, external scientific engagement, and launch readiness in a late-emerging biotech environment, where individual impact is high and scientific accountability matters.

Your role

Primary Focus: Solid tumors (pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC)

Scientific Exchange & External Engagement

Build and sustain deep, credible relationships with priority investigators, KOLs, and emerging scientific leaders in PDAC and NSCLC

Conduct high-quality, fair-balanced scientific exchange in response to unsolicited requests, grounded in a strong understanding of Tango’s biology, clinical data, and development strategy

Serve as a trusted scientific partner on disease biology, treatment paradigms, and evolving standards of care, particularly in high-unmet-need settings such as PDAC

Clinical Development & Trial Execution Support

Support Tango-sponsored clinical trials, with emphasis on:

Site identification and activation

Enrollment support and investigator engagement

Ongoing scientific dialogue to enhance trial conduct

Act as a Medical Affairs bridge between investigators and internal Clinical Development and Clinical Operations teams

Contribute field-based perspective to protocol feasibility, study design considerations, and operational execution

Insight Generation & Strategic Contribution

Capture and synthesize high-quality, hypothesis-driven insights from the field related to:

Trial design and execution

Competitive landscape

Future evidence needs

Translate insights into actionable feedback that informs Medical Strategy, Clinical Development, and future regulatory and commercialization readiness

Contribute to refinement of Tango’s core scientific narrative as programs mature and data evolve

Advisory Boards, Congresses & Scientific Presence

Support planning and execution of advisory boards, investigator meetings, and other scientific forums

Represent Tango at major medical and scientific congresses relevant to PDAC, NSCLC, and precision oncology

Maintain up-to-date knowledge of relevant literature, competitive activity, and guideline evolution

Cross-Functional Collaboration & Compliance

Collaborate closely with Medical Affairs leadership, Medical Content, Clinical Development, Regulatory, and other cross-functional partners

Serve as a scientific resource to internal stakeholders

Uphold the highest standards of compliance, scientific integrity, and ethical engagement

What You Bring

Education & Experience

8 years of relevant experience with a bachelor’s degree, 6 years with a master’s degree, or 3 years with an advanced scientific or medical degree (e.g., PharmD, PhD, MD) Candidates with advanced clinical degrees (e.g., NP, PA) and significant oncology Medical Science Liaison experience will also be considered.

Experience in PDAC, GI malignancies, or NSCLC strongly preferred

Prior experience supporting clinical-stage or pre-launch oncology assets highly valued

Skills & Attributes

Strong scientific acumen with the ability to engage deeply on complex biology and emerging clinical data

Demonstrated strength in insight generation, synthesis, and communication

Comfortable operating in a fast-moving, high-accountability biotech environment

Excellent collaboration skills across matrixed teams

Strong understanding of U.S. clinical research and healthcare environments

Compliance & Technical Requirements

Working knowledge of FDA, OIG, ICH, GCP, PhRMA Code, and applicable compliance standards

Commitment to compliant, ethical scientific exchange

Proficiency in standard business and field tools (CRM, MS Office, virtual engagement platforms)

Work Environment

Field-based role in the Northeast (Boston/New York), with residence required within assigned territory

~ 50% domestic travel expected, with significant time spent with external scientific partners

Why Join Tango Medical Affairs?

Be part of a Medical Affairs team built for a transition from mid-stage to late-stage development

Contribute directly to trial success, data readiness, and future regulatory and commercialization pathways

Expand and establish Tango as a credible clinical scientific leader in precision oncology

Work in a lean, collaborative environment where your scientific judgment and execution matter

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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Salary range
$157,600—$236,400 USD

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